PN / PDRN Skin Regeneration Program

Discover a regenerative approach to healthier-looking skin with PN and PDRN, injectable treatments designed to support the skin’s natural repair processes. Rather than adding volume or changing facial structure, these treatments focus on improving hydration, texture, elasticity, and skin quality.

Introduction to PN and PDRN

Polynucleotide (PN) and Polydeoxyribonucleotide (PDRN) are purified DNA-derived compounds obtained from salmon or trout. They are used in regenerative and aesthetic medicine to support tissue recovery and improve ageing, dehydrated, dull, or damaged skin.

Although PN and PDRN are related, they are not exactly the same. PN consists of longer DNA chains that provide structural and hydrating support, while PDRN contains shorter DNA fragments associated with cellular repair pathways.

How PN / PDRN Works

PN and PDRN help create a supportive environment for skin regeneration. Once injected, they may promote hydration, support fibroblast activity, and encourage the maintenance of collagen and the extracellular matrix. This process can improve skin smoothness, firmness, and resilience.

Unlike dermal fillers, PN and PDRN are not designed to create immediate volume. Their effects develop progressively, making them suitable for patients seeking subtle improvements.

Ideal Candidates

PN and PDRN may be suitable for individuals experiencing dehydrated skin, fine lines, reduced elasticity, uneven texture, dullness, or delicate under-eye skin. Treatment areas include the face, under-eye region, neck, décolletage, and hands.

The treatment may benefit those who prefer a non-surgical approach to improving skin quality. Patients seeking lifting, contouring, or volume replacement may require other treatments after medical assessment.

Benefits of PN / PDRN

Potential benefits include improved hydration, smoother texture, better elasticity, softer-looking fine lines, enhanced skin resilience, and a healthier appearance.

Preparing for Treatment

Before treatment, patients should inform the physician about their medical history, allergies, medications, previous aesthetic procedures, and active skin conditions. Alcohol and unnecessary supplements that may increase bruising should be avoided. Prescribed medication should not be stopped without medical advice.

Treatment should be postponed if there is an active infection, rash, inflammation, or cold sore.

Procedure Overview

A consultation is performed to assess the skin and select the appropriate product and injection technique. Topical anaesthetic may be applied for comfort. The product is then delivered through multiple small injections, with the session taking around 30–45 minutes.

Results and Longevity

Some patients notice improved hydration within the first few weeks, while changes in texture and elasticity develop gradually. A course of approximately three sessions, spaced two to four weeks apart, may be recommended. Maintenance treatment may be considered every four to six months.

Aftercare and Precautions

Temporary redness, swelling, tenderness, bruising, or small raised bumps may occur and improve within a few days. Patients should avoid rubbing the area, strenuous exercise, alcohol, excessive heat, and makeup for the recommended period. Gentle skincare and regular sunscreen use are advised.

Conclusion

PN and PDRN offer a regenerative approach to skin rejuvenation by focusing on hydration, repair, and skin quality. A medical consultation is essential to determine the most suitable product, technique, and treatment schedule.